Have you ever been so absorbed in watching a movie or reading a book to lose track of time and space?
Some say it can even be considered a hypnotic state. Here, now imagine being able to focus totally and totally your attention for hours on your work or on your study, without perceiving any principle of fatigue: what results could you achieve?
We know better the “Smart Drug” that is popular among English and not only university students which is Modafinil or Modalert.
Modafinil is one of the nootropic substances (nous : intellect, tropein : change) that are perfectly legal, that act on the brain and increase remarkable the individual’s attention threshold, as well as learning and memory skills.
Sold with the trade name of Provigil, it is a drug that in Italy is prescribed to treat mainly pathologies such as narcolepsy or ADHD: it is in fact a “eugeroico”, which is a promoter of wakefulness.
But how does it act exactly?
Although there is no absolute certainty about its mechanism of functioning. Several studies claim that Modafinil exponentially increases the release of histamine at the hypothalamic level: the effects of histamine in the brain are well documented, including a crucial role in maintaining of the state of vigilance during the vigil, in the implementation of behaviors aimed at gratification and in the acquisition of short and long-term memory.
According to other studies, now actually more accredited, Modafinil would trigger a reward circuit at the Nucleus Accumbens level, binding (in the form of false ligand) to at least 50% of dopamine transporters. Therefore, by inhibiting the reuptake of this neurotransmitter, it causes a considerable increase at the extracellular level.
Nucleus Accumbens is a region of the basal forebrain which is part of the mesolimbic system: the latter is related to the reward(reward and gratification) circuit of man, where primary needs are considered primary “rewards” such as drinking, eating, reproducing and breastfeeding, clearly indispensable actions for the survival of the species; Secondary rewards can be money, drugs, alcohol and more.
Here is the full video about modafinil:
In conclusion, therefore, the Modafinil, with a mechanism similar to that of cocaine (even if no episodes of addiction have been documented), on the one hand actually makes us more vigilant and insensitive to fatigue, on the other hand it would make studying, working, or even dialogue a stimulus so rewarding that you prefer it to any other action or distraction. It is easily available on RXShopMD.com
Clearly not all that glitters is gold: Although no cases of addiction have been ascertained, some dose-dependent side effects have been documented in some subjects: among the most common we mention headache, dizziness, somnolence, nervousness, insomnia, anxiety, tachycardia, palpitations, abdominal pain, nausea and diarrhea.